New Therapeutic Approaches to Osteoradionecrosis: Literature Review

Clinico-therapeutic management of osteoradionecrosis: a literature review and update.

In the management of head and neck cancer, radiotherapy is usually a coadjuvant to surgery, or is applied on a palliative basis. The most important complication of such radiotherapy is osteoradionecrosis, which manifests as an area of exposed necrotic bone in the maxillae or mandible that fails to heal during at least three months. In most cases osteoradionecrosis gradually progresses, becoming...

A Review of Oral Submucousal Fibrosis, Related Factors, Prognosis and New Therapeutic Approaches

Abstract   BACKGROUNackground and AIMD & AIM: Oral Submucous Fibrosis (OSF) is an oral premalignant condition with highest premalignant potential  among oral precancerous lesions which characterized with inflammation and  progressive fibrosis of  submucosal oral tissues (cause to significant irreversible rigidity and trismus). During the years, many classification systems have been propo...

Transfusion Related Adverse Effects on Beta-Thalassemia Major and New Therapeutic Approaches: A Review Study

Thalassemia is one of the most common genetic disorders, worldwide.Beta-Thalassemia Major (BTM) is the most severe type, which reduces lifeexpectancy and quality of life. In this study, we searched the related keywords to subject from 1996-2019 in the Medline and Web of Science databases, therefore found 250 articles. Moreover, we categorized them into the studies on blood transfusions in...

New perspectives on the conservative management of osteoradionecrosis of the mandible: A literature review.

Over the last decades, several therapeutic options were considered in the treatment of the osteoradionecrosis (ORN) of the mandible, including supportive measures, ultrasound therapy, corticosteroids, hyperbaric oxygen, surgical resection with reconstruction, and, more recently, drugs capable of reversing the fibroatrophic process. Once established, the ORN does not spontaneously disappear and ...

A review of theoretical approaches to light therapy in therapeutic spaces